{"id":1748,"date":"2022-11-19T03:18:33","date_gmt":"2022-11-19T03:18:33","guid":{"rendered":"http:\/\/example.com\/?p=751"},"modified":"2022-11-19T03:18:33","modified_gmt":"2022-11-19T03:18:33","slug":"751-cmap-analysis","status":"publish","type":"post","link":"https:\/\/w1.geleleger.nl\/rtgsk-751-cmap-analysis-unbrs\/","title":{"rendered":"Cmap Analysis"},"content":{"rendered":"<div class=\"a1420ecab7e2234e1f4e9be5cee323bb\" data-index=\"1\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<script type=\"text\/javascript\">\r\n\tatOptions = {\r\n\t\t'key' : '4a1f1119f949a4af74d56b8a3af8b867',\r\n\t\t'format' : 'iframe',\r\n\t\t'height' : 250,\r\n\t\t'width' : 300,\r\n\t\t'params' : {}\r\n\t};\r\n\tdocument.write('<scr' + 'ipt type=\"text\/javascript\" src=\"http' + (location.protocol === 'https:' ? 's' : '') + ':\/\/bleedingofficecontagion.com\/4a1f1119f949a4af74d56b8a3af8b867\/invoke.js\"><\/scr' + 'ipt>');\r\n<\/script>\n<\/div>\n\n<p><strong>Cmap Analysis<\/strong>. <strong>To enhance accessibility and utility, we developed a. Second, on-treatment biopsy coupled to CMap analysis may prove useful as an early molecular readout of target engagement in patients. The fundamental unit of CMap analysis is the query. Contact: cmap@broadinstitute.org What We Do The sequencing of the human genome has led to an explosion of new insights into the genetic basis of disease. Go to: Abstract Large-scale perturbation databases, such as Connectivity Map (CMap) or Library of Integrated Network-based Cellular Signatures (LINCS), provide enormous opportunities for computational pharmacogenomics and drug design. In the connectivity map (CMap) approach to drug repositioning and development, transcriptional signature of disease is constructed by differential gene expression analysis between the diseased tissue or cells and the control. A query (q) consists of a set of genes corresponding to any biological state of interest. Thus each query yields a pair of mutually exclusive gene lists (q up, q down).<\/strong><\/p>\n<p><figure> \t\t<img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/profile\/Violetta_Leshchenko\/publication\/258215539\/figure\/fig1\/AS:424742730637312@1478277966791\/Gene-expression-CMAP-analysis-and-profiling-of-aberrantly-methylated-genes-identify.png\" alt=\"Gene expression, CMAP analysis, and profiling of aberrantly methylated ...\" style=\"width: 100%; padding: 5px; background-color: grey;\"><figcaption>Gene expression, CMAP analysis, and profiling of aberrantly methylated &#8230; (Edward Ingram)<\/figcaption><\/figure>\n<p> \t \t<strong>Cmap Analysis<\/strong>. <strong>Rangelands have a dynamic response to climate change, fire, and other anthropogenic disturbances. The IHMC Cmap Tools software application uses the.cmap file suffix. Each gene in the query carries a sign indicating whether it is up-regulated or down-regulated. The brainstorming diagrams created with the software are saved with the.cmap file suffix. US Department of Commerce, NOAA, Physical Sciences Laboratory.<\/strong> Cmap Analysis. <\/p>\n<h3>In the connectivity map (CMap) approach to drug repositioning and development, transcriptional signature of disease is constructed by differential gene expression analysis between the diseased tissue or cells and the control.<\/h3>\n<p>This program is used to create mind-map diagrams for use during a brainstorming process.<\/p>\n<div style=\"display: grid;grid-template-columns: auto auto auto; background: #eee; \">\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.researchgate.net\/publication\/324815076\/figure\/fig1\/AS:620204136603648@1524879597146\/Connectivity-map-CMap-analysis-A-The-enrichment-scores-of-the-top-10-chemical-drugs.png\"><img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/publication\/324815076\/figure\/fig1\/AS:620204136603648@1524879597146\/Connectivity-map-CMap-analysis-A-The-enrichment-scores-of-the-top-10-chemical-drugs.png\" onerror=\"this.onerror=null;this.src='https:\/\/tse3.mm.bing.net\/th?id=OIP.-yhI8jdcgYpHSqMH48NVeAHaBz&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Connectivity map (CMap) analysis. (A) The enrichment scores of the top &#8230;<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.researchgate.net\/publication\/355965213\/figure\/fig1\/AS:1087146035281925@1636207221682\/Main-analysis-flowchart-Identification-of-distinguishing-metabolites-of-rat-pulmonary.png\"><img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/publication\/355965213\/figure\/fig1\/AS:1087146035281925@1636207221682\/Main-analysis-flowchart-Identification-of-distinguishing-metabolites-of-rat-pulmonary.png\" onerror=\"this.onerror=null;this.src='https:\/\/tse4.mm.bing.net\/th?id=OIP.tZZovuPqVAv49bAk3CWbTQHaET&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>| Main analysis flowchart. Identification of distinguishing metabolites &#8230;<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"http:\/\/cmap.ihmc.us\/docs\/images\/CmapViewer\/CmapViewer-Screenshot.PNG\"><img decoding=\"async\" src=\"http:\/\/cmap.ihmc.us\/docs\/images\/CmapViewer\/CmapViewer-Screenshot.PNG\" onerror=\"this.onerror=null;this.src='https:\/\/tse4.mm.bing.net\/th?id=OIP.7r5KCB995KEmp_JLNwPJhgHaG8&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Cmap | Cmap Software<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div style=\"display: grid;grid-template-columns: auto auto auto; background: #eee; \">\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.researchgate.net\/publication\/338580262\/figure\/tbl2\/AS:847230961471489@1579007010218\/Summary-of-four-datasets-sensitive-vs-resistant-cells-used-for-CMap-analysis.png\"><img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/publication\/338580262\/figure\/tbl2\/AS:847230961471489@1579007010218\/Summary-of-four-datasets-sensitive-vs-resistant-cells-used-for-CMap-analysis.png\" onerror=\"this.onerror=null;this.src='https:\/\/tse2.mm.bing.net\/th?id=OIP.uABkLitARWi-Yt-Cb4uVYAHaCO&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Summary of four datasets (sensitive vs. resistant cells) used for CMap &#8230;<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.researchgate.net\/profile\/Woody_Lin\/publication\/51800456\/figure\/fig5\/AS:340108235558918@1458099530332\/Flowchart-and-comparisons-of-prediction-accuracy-A-The-CMap-analysis-flowchart-All_Q640.jpg\"><img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/profile\/Woody_Lin\/publication\/51800456\/figure\/fig5\/AS:340108235558918@1458099530332\/Flowchart-and-comparisons-of-prediction-accuracy-A-The-CMap-analysis-flowchart-All_Q640.jpg\" onerror=\"this.onerror=null;this.src='https:\/\/tse2.mm.bing.net\/th?id=OIP.KUmdYVG6Z6hJTxkAvEJQagHaHa&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Flowchart and comparisons of prediction accuracy. (A) The CMap analysis &#8230;<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.frontiersin.org\/files\/Articles\/584164\/fgene-12-584164-HTML-r1\/image_m\/fgene-12-584164-t002.jpg\"><img decoding=\"async\" src=\"https:\/\/www.frontiersin.org\/files\/Articles\/584164\/fgene-12-584164-HTML-r1\/image_m\/fgene-12-584164-t002.jpg\" onerror=\"this.onerror=null;this.src='https:\/\/tse4.mm.bing.net\/th?id=OIP.6grq5R36yi6KGtvkHnZp4wHaEe&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Frontiers | Four Novel Prognostic Genes Related to Prostate Cancer &#8230;<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div style=\"display: grid;grid-template-columns: auto auto auto; background: #eee; \">\n<div style=\"padding: 1em;\"> \t\t        <a href=\"http:\/\/connections-pro.com\/wp-content\/uploads\/cmap-template-screenshot-600x352.png\"><img decoding=\"async\" src=\"http:\/\/connections-pro.com\/wp-content\/uploads\/cmap-template-screenshot-600x352.png\" onerror=\"this.onerror=null;this.src='https:\/\/tse1.mm.bing.net\/th?id=OIP.Bn--c9LCLmbo08_EImLxCwHaEW&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>cMap Documentation<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.researchgate.net\/publication\/358182852\/figure\/tbl1\/AS:1119397905215501@1643896666719\/Results-of-the-CMap-analysis-The-compounds-are-classified-according-to-their-score_Q640.jpg\"><img decoding=\"async\" src=\"https:\/\/www.researchgate.net\/publication\/358182852\/figure\/tbl1\/AS:1119397905215501@1643896666719\/Results-of-the-CMap-analysis-The-compounds-are-classified-according-to-their-score_Q640.jpg\" onerror=\"this.onerror=null;this.src='https:\/\/tse3.mm.bing.net\/th?id=OIP.5Obj8_tY2ZOa5SGdU4yZHwHaHa&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Results of the CMap analysis. The compounds are classified according to &#8230;<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/www.cmap.illinois.gov\/documents\/10180\/126253\/figure_4_historical_projected_rental-5-31-13.jpg\/ae91ac15-5e18-47ea-b2cc-b07d5f96564e?t=1385393963799\"><img decoding=\"async\" src=\"https:\/\/www.cmap.illinois.gov\/documents\/10180\/126253\/figure_4_historical_projected_rental-5-31-13.jpg\/ae91ac15-5e18-47ea-b2cc-b07d5f96564e?t=1385393963799\" onerror=\"this.onerror=null;this.src='https:\/\/tse3.mm.bing.net\/th?id=OIP.temJpgoslTmdx05u8suomgHaFv&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>Tip Sheet, 6-21-13 &#8211; CMAP<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<div style=\"display: grid;grid-template-columns: auto auto auto; background: #eee; \">\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/cmapskm.ihmc.us\/?rid=1064009710027_490725524_27110&amp;partName=htmljpeg\"><img decoding=\"async\" src=\"https:\/\/cmapskm.ihmc.us\/?rid=1064009710027_490725524_27110&amp;partName=htmljpeg\" onerror=\"this.onerror=null;this.src='https:\/\/tse3.mm.bing.net\/th?id=OIP.DpI6eyctSuv3vaSVRdVxegHaFB&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>CmapTools &#8211; Network Architecture<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"https:\/\/image.slidesharecdn.com\/sinttulo1j-110327152943-phpapp01\/95\/cmap-1-728.jpg?cb=1301239813\"><img decoding=\"async\" src=\"https:\/\/image.slidesharecdn.com\/sinttulo1j-110327152943-phpapp01\/95\/cmap-1-728.jpg?cb=1301239813\" onerror=\"this.onerror=null;this.src='https:\/\/tse3.mm.bing.net\/th?id=OIP.l731CRwUvYr99xcTTfipKAHaJ2&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>cmap<\/p>\n<\/p><\/div>\n<div style=\"padding: 1em;\"> \t\t        <a href=\"http:\/\/cmapspublic3.ihmc.us\/rid=1169186529910_1806856270_12062\/ARP%20Data%20Analysis.cmap?rid=1169186529910_1806856270_12062&amp;partName=htmljpeg\"><img decoding=\"async\" src=\"http:\/\/cmapspublic3.ihmc.us\/rid=1169186529910_1806856270_12062\/ARP%20Data%20Analysis.cmap?rid=1169186529910_1806856270_12062&amp;partName=htmljpeg\" onerror=\"this.onerror=null;this.src='https:\/\/tse1.mm.bing.net\/th?id=OIP.o0Eo5t0WXp5clTumg2Ud8QHaBy&amp;pid=Api';\" style=\"width:100%;margin-top: 8px;vertical-align: middle;\"><\/a> \t\t        <\/p>\n<p>ARP Data Analysis &#8211; How can we qualitatively analyze responses to the &#8230;<\/p>\n<\/p><\/div>\n<\/p><\/div>\n<p><strong>Cmap Analysis<\/strong>. <strong>Thus each query yields a pair of mutually exclusive gene lists (q up, q down). Next, the identified DEGs are used in the connectivity map (CMap) analysis to identify similarly acting therapeutic candidates. Rate it: CMAP: Compound Muscle Action Potentials. Looking for online definition of CMAP or what CMAP stands for? CMAP is a database in which mRNA expression levels of cells treated with different small molecule drugs are stored according to the degree of upregulation or downregulation compared with the control group.<\/p>\n<p><\/strong> Cmap Analysis.<\/p>\n<div class=\"a1420ecab7e2234e1f4e9be5cee323bb\" data-index=\"2\" style=\"float: none; margin:10px 0 10px 0; text-align:center;\">\n<script type=\"text\/javascript\">\r\n\tatOptions = {\r\n\t\t'key' : '4a1f1119f949a4af74d56b8a3af8b867',\r\n\t\t'format' : 'iframe',\r\n\t\t'height' : 250,\r\n\t\t'width' : 300,\r\n\t\t'params' : {}\r\n\t};\r\n\tdocument.write('<scr' + 'ipt type=\"text\/javascript\" src=\"http' + (location.protocol === 'https:' ? 's' : '') + ':\/\/bleedingofficecontagion.com\/4a1f1119f949a4af74d56b8a3af8b867\/invoke.js\"><\/scr' + 'ipt>');\r\n<\/script>\n<\/div>\n\n<div style=\"font-size: 0px; height: 0px; line-height: 0px; margin: 0; padding: 0; clear: both;\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Cmap Analysis. To enhance accessibility and utility, we developed a. Second, on-treatment biopsy coupled to CMap analysis may prove useful as an early molecular readout of target engagement in patients. The fundamental unit of CMap analysis is the query. Contact: cmap@broadinstitute.org What We Do The sequencing of the human genome [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/posts\/1748"}],"collection":[{"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/comments?post=1748"}],"version-history":[{"count":0,"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/posts\/1748\/revisions"}],"wp:attachment":[{"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/media?parent=1748"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/categories?post=1748"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/w1.geleleger.nl\/wp-json\/wp\/v2\/tags?post=1748"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}